Reproduction Abstracts

Introduction: This work adapts a novel ovary culture technique, devised by De Felici’s group, for assessing the ovotoxicity of two chemotherapeutic drugs, cisplatin and doxorubicin. Previous work from our laboratory used cultures of intact neonatal ovaries to determine the effects of the two drugs, showing that both cisplatin and doxorubicin are moderately ovotoxic.Methods: Here, ovaries collected from newborn WT mice were cultured as by De Felici. ...

Introduction: The endometrium is one of the few adult tissues that heals repeatedly without scarring. On a monthly basis the endometrium undergoes cyclical episodes of proliferation, degeneration, tissue repair and remodelling in response to the ‘injury’ inflicted on it during menstruation. In women, endometrial shedding (menses) is the culmination of a cascade of inflammatory signals between uterine stromal cells and immune cells both of which have key roles in endo...